Inflammation is an underlying cause of chronic disease, we now also know that if left unaddressed, inflammation cannot resolve itself and progression of chronic disease may in fact be accelerated. Recent studies have revealed when patients are deficient in their ability to resolve inflammation, there is a progression in chronic disease states – this deficiency has been described in an increasing number of chronic disease states including obesity or metabolic syndrome, diabetes, cardiovascular diseases, mild cognitive impairment, compromised digestive function (e.g., IBS, IBD, SIBO etc.), certain autoimmune conditions, Lyme disease, chronic obstructive pulmonary disease, arthritis (rheumatoid and osteoarthritic), and a variety of other chronic conditions often complicated by chronic pain. Read more at Metagenics Institute
FACT: Inflammation is an immune response to insults such as injuries (e.g., cuts and wounds), infections (e.g., bacterial, viral or fungal), or unhealthy dietary patterns. Although an inflammatory response is an essential, protective response, it can give rise to chronic inflammation if left unresolved.
FACT: The Body makes SPMs during the inflammation process: During the resolution phase of an inflammatory response, SPMs are biosynthesized (through multiple steps of enzymatic reactions) from long-chain polyunsaturated fatty acids and especially omega-3 fatty acids EPA and DHA.2,3 SPMs themselves are structurally different from omega-3 fatty acids.
FACT: SPMs do not inhibit the initiation phase of inflammation. Rather, SPMs help facilitate the clearance of inflammatory components and thus resolve the inflammatory response.
SPMs limit the immune response.